abstract：:Placental extracts have been widely used as skin lightening agents in the Japanese cosmetic market. Here, we show that placental extracts contain factors that can decrease or increase melanin synthesis by normal human melanocytes in vitro in possible association with mitochondrial respiration. When normal human melano...

journal_title：Experimental dermatology

authors： Yoshimoto S,Ohagi Y,Yoshida M,Yanagi H,Hibino S,Ichihashi M,Ando H

更新日期：2019-02-01 00:00:00

abstract：:Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins and protectins. LOX and COX pathways are important for the regulation of pro-inflammatory or pro-resolving metabolite synthesis and metabolism for v...

journal_title：Experimental dermatology

authors： Töröcsik D,Weise C,Gericke J,Szegedi A,Lucas R,Mihaly J,Worm M,Rühl R

更新日期：2019-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic...

journal_title：Experimental dermatology

authors： Henrot P,Truchetet ME,Fisher G,Taïeb A,Cario M

更新日期：2019-01-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...

journal_title：Experimental dermatology

authors： Simon B,Uslu U

更新日期：2018-12-01 00:00:00

abstract：:SHARPIN is an important component of the linear ubiquitin chain assembly complex (LUBAC). Loss of function of SHARPIN results in eosinophilic inflammation in multiple organs including skin with Th2 -dominant cytokines and dysregulated development of lymphoid tissues in mice. The clinicopathological features are simila...

journal_title：Experimental dermatology

authors： Tang L,Wang J,Zhu J,Liang Y

更新日期：2018-12-01 00:00:00

abstract：:Nilotinib (AMN), a second-generation tyrosine kinase inhibitor, induces apoptosis in various cancer cells, and our recent study showed that AMN effectively reduced the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis. The effect of AMN in the melanogenesis of melanoma cells is still unclea...

journal_title：Experimental dermatology

authors： Chang SP,Huang HM,Shen SC,Lee WR,Chen YC

更新日期：2018-12-01 00:00:00

abstract：:DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...

journal_title：Experimental dermatology

authors： Zhou L,Jing J,Wang H,Wu X,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studie...

journal_title：Experimental dermatology

authors： Suhng E,Kim BH,Choi YW,Choi HY,Cho H,Byun JY

更新日期：2018-09-01 00:00:00

abstract：:Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atop...

journal_title：Experimental dermatology

authors： Mathyer ME,Quiggle AM,Wong XFCC,Denil SLIJ,Kumar MG,Ciliberto HM,Bayliss SJ,Common JE,de Guzman Strong C

更新日期：2018-09-01 00:00:00

abstract：:Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epider...

journal_title：Experimental dermatology

authors： Rogerson C,O'Shaughnessy RFL

更新日期：2018-08-01 00:00:00

abstract：:Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occu...

journal_title：Experimental dermatology

authors： Jakasa I,Thyssen JP,Kezic S

更新日期：2018-08-01 00:00:00

abstract：:4-(4-Hydroxyphenyl)-2-butanol (rhododendrol, RD), a skin-whitening agent, was reported to cause skin depigmentation in some users, which is attributed to its cytotoxicity to melanocyte. It was reported that cytotoxicity to melanocyte is possibly mediated by oxidative stress in a tyrosinase activity-dependent manner. W...

journal_title：Experimental dermatology

authors： Goto N,Tsujimoto M,Nagai H,Masaki T,Ito S,Wakamatsu K,Nishigori C

更新日期：2018-07-01 00:00:00

abstract：:Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in c...

journal_title：Experimental dermatology

authors： Nicu C,Pople J,Bonsell L,Bhogal R,Ansell DM,Paus R

更新日期：2018-06-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation o...

journal_title：Experimental dermatology

authors： Schmidt T,Mauracher S,Bender L,Greene B,Kurzhals J,Eming R,Dostatni R,Hertl M

更新日期：2018-03-01 00:00:00

abstract：:The process of skin wound healing involves the following three steps: inflammation, tissue formation and tissue remodelling. These optimal steps are required for the development of normal wound healing. Recent reports demonstrated that inflammasomes are involved in the innate immune response. In the present study, we ...

journal_title：Experimental dermatology

authors： Ito H,Kanbe A,Sakai H,Seishima M

更新日期：2018-01-01 00:00:00

abstract：:Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra-epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal inter...

journal_title：Experimental dermatology

authors： Talagas M,Lebonvallet N,Leschiera R,Marcorelles P,Misery L

更新日期：2018-01-01 00:00:00

abstract：:The potentially severe side effects of systemic corticosteroids and immunosuppressants used in Pemphigus vulgaris (PV) call for novel therapeutic approaches. In this context, pharmacological inhibition of major pathogenic signalling effectors represents a promising alternative. However, we have also shown that overinh...

journal_title：Experimental dermatology

authors： Hariton WVJ,Galichet A,Vanden Berghe T,Overmiller AM,Mahoney MG,Declercq W,Müller EJ

更新日期：2017-12-01 00:00:00

abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

journal_title：Experimental dermatology

authors： Simon D,Borradori L,Simon HU

更新日期：2017-12-01 00:00:00

abstract：:Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, ...

journal_title：Experimental dermatology

authors： Kunz N,Hauenschild E,Maass S,Kalies KU,Klinger M,Barra M,Hecht L,Helbig F,Soellner S,Caldwell CC,Ludwig RJ,Westermann J,Kalies K

更新日期：2017-12-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86-/- ) mice. Incidence and severity of alopec...

journal_title：Experimental dermatology

authors： Bae JH,Hwang WS,Jang YJ,Lee YH,Jang DE,Kim JS,Yeom SC

更新日期：2017-11-01 00:00:00

abstract：:Hair follicle heterogeneity may be regulated by distinct dermal papillae (DP) that represent mesenchymal lineages, which can be defined by Sox2 expression. However, it was recently shown that GFP expression in the Sox2: GFP+/- mouse model occurs in the DPs of all hair follicle types, challenging the idea that hair fol...

journal_title：Experimental dermatology

authors： Salz L,Driskell RR

更新日期：2017-11-01 00:00:00

abstract：:Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have i...

journal_title：Experimental dermatology

authors： Niyonsaba F,Kiatsurayanon C,Chieosilapatham P,Ogawa H

更新日期：2017-11-01 00:00:00

abstract：:Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid-phase micro-extraction fibre permitting rapid enclosed headspace sampli...

journal_title：Experimental dermatology

authors： Duffy E,Jacobs MR,Kirby B,Morrin A

更新日期：2017-10-01 00:00:00

abstract：:In the last decade, significant progress has been made in understanding skin cancer cell death resistance mechanisms, and a number of new treatment strategies have been developed. Systematic approach genomic studies of various cancer types have opened new possibilities for the development of anticancer therapies. Howe...

journal_title：Experimental dermatology

authors： Feoktistova M,Panayotova-Dimitrova D

更新日期：2017-10-01 00:00:00

abstract：:The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasian populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in Asian populations is limited. To describe the molecular nature of AM in Korean ...

journal_title：Experimental dermatology

authors： Shim JH,Shin HT,Park J,Park JH,Lee JH,Yang JM,Kim DH,Jang KT,Lee DY

更新日期：2017-10-01 00:00:00

abstract：:Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-exp...

journal_title：Experimental dermatology

authors： Castela M,Linay F,Roy E,Moguelet P,Xu J,Holzenberger M,Khosrotehrani K,Aractingi S

更新日期：2017-09-01 00:00:00

abstract：:This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in vitro effect of ruxolitinib in cultured immortalize...

journal_title：Experimental dermatology

authors： Klaeschen AS,Wolf D,Brossart P,Bieber T,Wenzel J

更新日期：2017-08-01 00:00:00

abstract：:Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition ...

journal_title：Experimental dermatology

authors： Sangalli A,Malerba G,Tessari G,Rodolfo M,Gomez-Lira M

更新日期：2017-08-01 00:00:00

abstract：:The therapeutic hypothesis proposed by Speeckaert and van Geel in this issue (1) is based on the dramatic effects of the new drugs targeting immune privilege checkpoints (PD1/PDL, CTLA4) in current advanced melanoma therapy as major inductors of vitiligo changes in the skin. Such striking clinical manifestations canno...

journal_title：Experimental dermatology

authors： Boniface K,Seneschal J,Taïeb A,Merched A

更新日期：2017-07-01 00:00:00

abstract：:For decades, an extensive debate is continued on the pathophysiology of vitiligo. Numerous hypotheses have been put forward, and many supported by well-documented arguments. Regardless of the initiating steps, most experts agree that an immune-based melanocyte destruction is responsible for the final steps leading to ...

journal_title：Experimental dermatology

authors： Speeckaert R,van Geel N

更新日期：2017-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNA...

journal_title：Experimental dermatology

authors： Liu Q,Wu DH,Han L,Deng JW,Zhou L,He R,Lu CJ,Mi QS

更新日期：2017-04-01 00:00:00

abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

journal_title：Experimental dermatology

authors： Thieme M,Zillikens D,Sadik CD

更新日期：2017-03-01 00:00:00

abstract：:Current gold standard lower extremity cutaneous wound management is not always effective. Cutaneous wounds generate a "current of injury" which is directly involved in wound healing processes. Application of exogenous electrical stimulation has been hypothesised to imitate the natural electric current that occurs in c...

journal_title：Experimental dermatology

authors： Ashrafi M,Alonso-Rasgado T,Baguneid M,Bayat A

更新日期：2017-02-01 00:00:00

abstract：:Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern, and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair foll...

journal_title：Experimental dermatology

authors： Seo CH,Kwack MH,Kim MK,Kim JC,Sung YK

更新日期：2017-02-01 00:00:00

abstract：:The role of placebo and nocebo effects-that is positive or negative treatment effects that are entirely a consequence of the patient's expectations and beliefs about a treatment outcome in terms of efficacy, safety, usability or side effects-has been shown for almost all types of diseases and physiological response sy...

journal_title：Experimental dermatology

authors： Evers AW

更新日期：2017-01-01 00:00:00

abstract：:The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV-induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epider...

journal_title：Experimental dermatology

authors： Patra V,Wolf P

更新日期：2016-12-01 00:00:00

abstract：:The adoptive transfer of engineered T cells represents an important approach in immunotherapy of melanoma. However, relapse of the tumor can occur due to immune-escape mechanisms developed by the tumor cells, for example antigen loss, downregulation of the major histocompatibility complex presentation machinery and de...

journal_title：Experimental dermatology

authors： Uslu U,Schuler G,Dörrie J,Schaft N

更新日期：2016-11-01 00:00:00

abstract：:Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in ...

journal_title：Experimental dermatology

authors： Noh JY,Shin JU,Park CO,Lee N,Jin S,Kim SH,Kim JH,Min A,Shin MH,Lee KH

更新日期：2016-11-01 00:00:00